Ugh, not Foamy. x_o; Homestarrunner I enjoy. Though those two sites don't count as "comics," heheh.
VG Cats is fairly popular it seems, I've only read a few strips. I haven't heard many good things about Penny Arcade. o_0 Dunno about your friend's yet, I'll have to take a look at it. XD
I recommend...
Van Von Hunter - Fantasy/comedy about a hero and his adventures to destroy that which is evil within a kingdom that suffers from a spell inducing amnesia (as represented by his female side-kick who has no name). I like it, dunno if it's everyone's type of humor...
l33tpixelz - Comedy/drama video game-ish related comic as the main character jumps out of a second story window to save his PS2 and ends up in the hospital thinking that he is now the hero of a game and destined to save the world! Thus follows his antics of befriended other "party" members which includes a cactus (I love cactus). The real mystery is... is he really crazy or has he actually stumbled upon a great adventure to save the world? I'm not really sure. I've done some art for this one and I'm still confused. XD; Sadly this comic is currently on pause as the creater is focusing his energies towards creating a flash cartoon (which I hope to do a voice for. eek).
Esc - Fantasy comic that my current webhostess has going. I don't quite know how to describe this one, but it involves a scientist (Dr. X), his newly hired female assistant (Helen), and his robot girl "daughter" (Elbee) as they stumble into a world of fantasy. I personally like Gavriel, an angel who's supposed to watch over Dr. X, but neglected to stop a vengeful mail-man. XD Of course that's just the fangirl in me.
Um, I've finally got my webcomic started, though there's only a cover and one page up so far, so it seems kind of silly to advertise it, but...
Tag - Sci-fi/comedy? There's not much to say at the moment. The story follows two guys who travel through space taking on different jobs and stuff. Ones a fairly reserved techie from Mars, the other is a crazy Japanese guy from Earth. I'm just starting off with some character development for now before I delve into a bigger storyline. I also rate it PG-13 for language and violence. o_o;;;